Evolution of Bioactive Glass

Biosphere Particles

Optimal Sphere Particle Packing

  • 3-dimensional packing of spheres results in 100% interconnected porosity (no small pores or blocked off channels)

 

  • Optimal packing allows for bone growth throughout entire implant area

Irregular Particle packing

  • Irregular particles with small particles, sharp edges, and flat surfaces can pack into dense configurations

 

  • Dense packing can reduce bone in-growth due to small pore sizes and blocked off porosity.  This can limit bone growth to the periphery of the implant area.

Biosphere Particles

Bimodal Size Range

  • Due to the spherical shape, BioSphere particles can be precisely separated into narrow size ranges. 

 

  • A bimodal particle distribution can be created by combining specific size ranges.

  • The use of specific size ranges allows for control over the dissolution and ion release profile of bioactive glass.

  • Small particles resorb faster and generate ions more quickly than larger particles.  Larger particles resorb slower and function as a longer-term scaffold for bone formation.

Bimodal Size Range

In-vivo optimization study showed that a 10:90 mixture of small
(90-180 um) spheres and large (355-500 um) spheres provided
the best bone healing

Particle Settling

  • The spherical particles in Biomold Putty take up nearly the entire volume of the Putty while still maintaining an optimal porosity for bone in-growth.

  • This enables the bioactive glass particles to remain in contact with the edges of a bone defect after the carrier has been resorbed.

  • Other putties with lower particle content and irregular particles can settle following carrier resorption resulting in gaps between the implant material and the surrounding bone.

Particle Settling

By minimizing particle settling, Biomold Putty remains in
contact with the surrounding bone thereby improving the
bone healing response.